Detection of the Erythromycin rRNA Methylase Gene erm (A) in Enterococcus faecalis

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Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes.

Genes belonging to different erm DNA hybridization classes were selectively amplified by polymerase chain reaction with a pair of oligonucleotides that corresponded to conserved amino acid motifs in known ERM methylases. Identification of the resistance mechanism was possible despite substantial nucleotide sequence diversity among the erythromycin resistance genes.

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Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter.

Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients and food-producing animals. Constitutive expression of erm(B) was associated wit...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2008

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.00230-08